The project validates the samples and sequenced by the Consortium that are stored. These entities collect data and look for varieties genotypes chances of getting cancer. The ultimate goal is to do a meta-analysis and identify the most outstanding varieties.
We propose to develop bioinformatics tools at the interface of research in cohorts and clinical practice, thus greatly promoting translation of computational research. Moreover, the proposal covers broad aspects of the relevant pipelines, including medically relevant discovery of clinically important hits using state-of-the-art omics technologies, validation and the translational use to devise biomarkers for improved diagnostic and disease monitoring.
The research proposal builds and promotes European Notably, we will build on and develop novel analytical tools specifically to exploit data generated in the context of the European ICGC pan-cancer initiative, an important flagship project of international European research. The participants of the consortium and the projects this work is tied into have international standing, promoting European excellence at the interface of cancer genomics, statistical and computational biology and clinical translation.
We will implement a computational platform able to analyse NGS based cancer risk data, which will be capable of analysing vast data collections (such as the pan-cancer study with >10,000 cases), in addition to being intuitively usable by clinicians for personalized cancer genomics.
We consider a matter of extreme importance not only the development but also the implementation of intuitive computational tools for the day-to-day clinical practice. In order to support clinicians in diagnosis, decision-making, treatment selection, etc., we aim at making the wealth of medical genomics data accessible to oncologists. Therefore the resulting computational platform will be distributed under an open source license for genomic-based cancer risk tests assessment, for its use in clinical settings.
The laboratories and entities involved in the PanCanRisk consortium per se represent the first step of a professional dissemination program at a very early phase. They provide a solid basis for facilitated exchange of methods, knowledge and expertise, as well as giving access to a network of footholds for further regional dissemination.