AC Hotel Palacio del Carmen. Santiago de Compostela (Galicia-Spain)  8th-9th July 2015

The PanCanRisk project aims to apply bioinformatics for global identification of genetic susceptibility to cancer and clinical management. It is coordinated by the team of Professor Ángel Carracedo in the Fundación Pública Galega de Medicina Xenómica(FPGMX), and is part of the European Commission Program Horizon 2020. Our first meeting took place in Santiago de Compostela, in July 2015, with the aim of promoting the Pancanrisk project. In the first session, introduced by Ángel Carracedo, all the partners introduced ourselves and we knew our structure and organization.

Then, in the Scientific Work Packages, the partners analyzed their role in the project. Stephan Ossowski analyzed the development of a computational platform for sequencing-based cancer risk analysis and Xavier Stivill talked about the tools for rare and common variant association analyses in cancer studies. Next, Oliver Stegle explained the identification process of regulatory variants and eQTLS, integrating germline and somatic mutations and phenotypes.

Replication and clinical validation in cancer, with Anna Abulí, functional study of identified risk genes and regulatory variants, with Aura Carreira, and computational biomarker development for cancer predisposition genes with Mahesh Shah were also discussed.

On the second day, Domenico Lalli, legal officer at DG Research & Innovation European Commission, analyzed the practical aspects of Horizon 2020 projects and advices for PanCanRisk. Also, the ethical and legal issues were explained by Ángel Carracedo, who guided the project’s partners to a visit to Fundación Pública Galega de Medicina Xenómina and Innopharma.